Neoplan USA was a major transit bus manufacturing company based in Denver, Colorado, which was entirely

separate from the German corporation, Neoplan, licensing its designs from the German company of the same name. The company was founded in 1981 and folded in 2006. It was originally a subsidiary of Neoplan, but later became an independent licensee. Its main factory was located in Lamar, Colorado. Its headquarters was also in Lamar, until moving to Denver in 2004. At one time, it also had production facilities in Honey Brook, Pennsylvania, and Brownsville, Texas.

Neoplan manufactured standard floor  buses, low-floor buses, and articulated buses. In 2003–2006 it also built 28 40-foot (12 m) electric trolley buses and 32 articulated dual-mode buses for Boston's MBTA. Neoplan had 625 employees and revenue of $810 million before it ceased operations in January 2006.

Neoplan USA filed for Chapter 11 Bankruptcy Protection in August 2006, listing assets of $13.7 million and debts of $59 million, after closing its manufacturing plant in 2006.

In its last few months of operation, Neoplan had fallen on hard times, such as warranty issues with San Francisco's MUNI and cash-flow problems after Boston's MBTA canceled an order over late bus deliveries.

The company still technically continued to exist until selling its parts-supply division, Neopart. Once Neopart was sold, in October 2007, Neoplan USA ceased to exist.